Hspa1a^tm1Msk
Targeted Allele Detail

Summary

• Symbol: Hspa1a^tm1Msk
• Name: heat shock protein 1A; targeted mutation 1, Demetrius Moskophidis
• MGI ID: MGI:2183895
• Synonyms: hsp70.3^-
• Gene: Hspa1a Location: Chr17:35188335-35191132 bp, - strand Genetic Position: Chr17, 18.51 cM
• Alliance: Hspa1a^tm1Msk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72943
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding region of the gene (codons 1-633) was replaced with an in frame lacZ floxed TK-neo cassette via homologous recombination. Southern blot and PCR genotype analysis confirmed the targeted allele in homozygous mutant animals. (J:72943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspa1a Mutation: 24 strains or lines available

References

• Original: J:72943 Huang L, et al., Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice with Targeted Gene Disruption of the hsp70.1 or hsp70.3 Gene. Mol Cell Biol. 2001 Dec;21(24):8575-91
• All: 1 reference(s)