Mapk3^tm1Gpg
Targeted Allele Detail

Summary

• Symbol: Mapk3^tm1Gpg
• Name: mitogen-activated protein kinase 3; targeted mutation 1, Gilles Pages
• MGI ID: MGI:2183906
• Synonyms: ERK1^-, MAPK^-, p44 MAPK^-
• Gene: Mapk3 Location: Chr7:126358798-126364988 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Mapk3^tm1Gpg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted exonic sequence encoding the essential kinase subdomains 5 and 6. Immunoblot analysis of protein extracts from MEFs and various tissues showed an absence of protein in homozygous mutant mice. (J:58468)

Expression

In Mice Carrying this Mutation:	24 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk3 Mutation: 26 strains or lines available

References

• Original: J:58468 Pages G, et al., Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 1999 Nov 12;286(5443):1374-7
• All: 70 reference(s)