Foxb1^tm1Blh
Targeted Allele Detail

Summary

• Symbol: Foxb1^tm1Blh
• Name: forkhead box B1; targeted mutation 1, Brigid L Hogan
• MGI ID: MGI:2183919
• Synonyms: mf3^-, mf3^tm1blh-
• Gene: Foxb1 Location: Chr9:69664992-69668222 bp, - strand Genetic Position: Chr9, 38.76 cM
• Alliance: Foxb1^tm1Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40034
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region and 5' untranslated sequence were replace by a neomycin selection cassette. Transcript was undetected in the heads of homozygous mutant embryos via whole mount in situ hybridization. (J:40034)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxb1 Mutation: 16 strains or lines available

References

• Original: J:40034 Labosky PA, et al., The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development. 1997 APR;124(7):1263-1274
• All: 1 reference(s)