Muc2^tm1Avel
Targeted Allele Detail

Summary

• Symbol: Muc2^tm1Avel
• Name: mucin 2; targeted mutation 1, Anna Velcich
• MGI ID: MGI:2183923
• Synonyms: Muc2^-
• Gene: Muc2 Location: Chr7:141276583-141308428 bp, + strand Genetic Position: Chr7, 87.1 cM, cytoband F5
• Alliance: Muc2^tm1Avel page

Spontaneous colitis in Muc2^tm1Avel/Muc2^tm1Avel mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75047
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis detected a mutant Muc2-neo hybrid mRNA in homozygous mutant animals predicted to encode the first 26 amino acids of Muc2. Immunohistochemistry of intestine sections from homozygous mutants did not detect protein product. (J:75047)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Muc2^tm1Avel

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc2 Mutation: 81 strains or lines available

References

• Original: J:75047 Velcich A, et al., Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002 Mar 1;295(5560):1726-9
• All: 40 reference(s)