Cdc7^tm1Hmas
Targeted Allele Detail

Summary

• Symbol: Cdc7^tm1Hmas
• Name: cell division cycle 7; targeted mutation 1, Hisao Masai
• MGI ID: MGI:2183930
• Synonyms: muCdc7^-
• Gene: Cdc7 Location: Chr5:107112201-107132298 bp, + strand Genetic Position: Chr5, 51.43 cM, cytoband E
• Alliance: Cdc7^tm1Hmas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76497
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 encoding kinase domains I and II were replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of heterozygous ES cells did not detect aberrant protein products. (J:76497)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc7 Mutation: 34 strains or lines available

Notes

ES cell line = CCE 28 (CCE28).

References

• Original: J:76497 Kim JM, et al., Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 2002 May 1;21(9):2168-79
• All: 4 reference(s)