Xpa^tm1Tnka
Targeted Allele Detail

Summary

• Symbol: Xpa^tm1Tnka
• Name: xeroderma pigmentosum, complementation group A; targeted mutation 1, Kiyoji Tanaka
• MGI ID: MGI:2183931
• Synonyms: XPA-
• Gene: Xpa Location: Chr4:46175222-46196317 bp, - strand Genetic Position: Chr4, 24.49 cM, cytoband C2
• Alliance: Xpa^tm1Tnka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28709
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4 was disrupted by the insertion of a neomycin selection cassette. Encoded protein was undetected in homozygous mutant mice by Western blot analysis of splenocyte extracts. (J:28709)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Xpa^tm1Tnka

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xpa Mutation: 21 strains or lines available

Notes

ES cell line = F1/1 ES (established from the F1 hybrid of male CBA and female C57BL/6).

References

• Original: J:28709 Nakane H, et al., High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene. Nature. 1995 Sep 14;377(6545):165-8
• All: 35 reference(s)