Ercc1^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Ercc1^tm1Jhjh
• Name: excision repair cross-complementing rodent repair deficiency, complementation group 1; targeted mutation 1, Jan H J Hoeijmakers
• MGI ID: MGI:2183944
• Synonyms: Ercc1-
• Gene: Ercc1 Location: Chr7:19079016-19090449 bp, + strand Genetic Position: Chr7, 9.6 cM
• Alliance: Ercc1^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41161
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette. Expression analysis showed an absence of transcript in mouse embryonic fibroblasts derived from homozygous mutant mice. Further analysis showed that transcription of the antisense gene was unaffected by the targeting event. (J:41161)

Disease models

Expression

In Mice Carrying this Mutation:	7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ercc1 Mutation: 28 strains or lines available

References

• Original: J:41161 Weeda G, et al., Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol. 1997 Jun 1;7(6):427-39
• All: 48 reference(s)