Sh2b3^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Sh2b3^tm1Paw
• Name: SH2B adaptor protein 3; targeted mutation 1, Tony Pawson
• MGI ID: MGI:2383957
• Synonyms: Lnk^-
• Gene: Sh2b3 Location: Chr5:121953551-121975709 bp, - strand Genetic Position: Chr5, 61.99 cM
• Alliance: Sh2b3^tm1Paw page

Primary splenomegaly and extramedullary hematopoiesis in Sh2b3^tm1Paw/Sh2b3^tm1Paw mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77248
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.6 Kb of sequence, encompassing exons 2 through 7, was replaced with a neomycin selection cassette. The absence of transcript and protein was determined in homozygous mutant mice by Northern and Western blot analyses. (J:77248)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sh2b3 Mutation: 24 strains or lines available

References

• Original: J:77248 Velazquez L, et al., Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice. J Exp Med. 2002 Jun 17;195(12):1599-611
• All: 15 reference(s)