Vegfa^tm2.1Nagy
Targeted Allele Detail

Summary

• Symbol: Vegfa^tm2.1Nagy
• Name: vascular endothelial growth factor A; targeted mutation 2.1, Andras Nagy
• MGI ID: MGI:2383985
• Synonyms: VEGF^hypo, Vegf^lo
• Gene: Vegfa Location: Chr17:46327919-46343295 bp, - strand Genetic Position: Chr17, 22.79 cM
• Alliance: Vegfa^tm2.1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75937
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: The mutant is a derivative of Vegf1^tm2Nagy where the floxed PGK-neo cassette in exon 8 has been removed by mating to a cre deletor strain. (J:75937)

Expression

In Mice Carrying this Mutation:	88 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vegfa Mutation: 38 strains or lines available

References

• Original: J:75937 Damert A, et al., Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation. Development. 2002 Apr;129(8):1881-92
• All: 13 reference(s)