Folr1^tm1Fnn
Targeted Allele Detail

Summary

• Symbol: Folr1^tm1Fnn
• Name: folate receptor alpha; targeted mutation 1, Richard H Finnell
• MGI ID: MGI:2383986
• Synonyms: Folbp1-
• Gene: Folr1 Location: Chr7:101507551-101519974 bp, - strand Genetic Position: Chr7, 54.67 cM
• Alliance: Folr1^tm1Fnn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57765
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. The absence of normal transcript in homozygous mutant mice was determined via an RNAse protection assay. (J:57765)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Folr1 Mutation: 216 strains or lines available

References

• Original: J:57765 Piedrahita JA, et al., Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet. 1999 Oct;23(2):228-32
• All: 15 reference(s)