Fgf2^tm1Zllr
Targeted Allele Detail

Summary

• Symbol: Fgf2^tm1Zllr
• Name: fibroblast growth factor 2; targeted mutation 1, Rolf Zeller
• MGI ID: MGI:2384003
• Synonyms: FGF-2-, FGF2-
• Gene: Fgf2 Location: Chr3:37402616-37464255 bp, + strand Genetic Position: Chr3, 18.41 cM, cytoband A2-B
• Alliance: Fgf2^tm1Zllr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49141
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 2.3 kb of sequence spanning exon 1 was replaced with a neomycin selection cassette. Western blot analysis of homozygous mutant mice showed an absence of the 3 isoforms produced from the endogenous locus as well as a lack of aberrantly truncated proteins. (J:49141)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf2 Mutation: 19 strains or lines available

References

• Original: J:49141 Dono R, et al., Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice. EMBO J. 1998 Aug 3;17(15):4213-25
• All: 21 reference(s)