Fcer1g^tm1Tks
Targeted Allele Detail

Summary

• Symbol: Fcer1g^tm1Tks
• Name: Fc receptor, IgE, high affinity I, gamma polypeptide; targeted mutation 1, Takashi Saito
• MGI ID: MGI:2384004
• Synonyms: Fcrg^-, FcRgamma-, gamma-
• Gene: Fcer1g Location: Chr1:171057141-171061918 bp, - strand Genetic Position: Chr1, 79.23 cM
• Alliance: Fcer1g^tm1Tks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50023
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was deleted and replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot and RT-PCR analyses. The absence of the protein product of the endogenous locus was shown by FACS analysis of natural killer cells, macrophages, and neutrophils obtained from homozygous mutant mice. (J:50023)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fcer1g Mutation: 28 strains or lines available

References

• Original: J:50023 Park SY, et al., Resistance of Fc receptor- deficient mice to fatal glomerulonephritis. J Clin Invest. 1998 Sep 15;102(6):1229-38
• All: 54 reference(s)