F11^tm1Gjb
Targeted Allele Detail

Summary

• Symbol: F11^tm1Gjb
• Name: coagulation factor XI; targeted mutation 1, George J Broze
• MGI ID: MGI:2384015
• Synonyms: FXI^-
• Gene: F11 Location: Chr8:45694211-45715068 bp, - strand Genetic Position: Chr8, 25.14 cM
• Alliance: F11^tm1Gjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40270
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 5, encoding a portion of the second apple domain, was disrupted by the insertion of a neomycin selection cassette. Sequence analysis showed that a frameshift mutation would be generated if exon 4 were to splice to exon 6 due to the excision of the disrupted exon 5. Transcript was undetected in homozygous mutant mice via Northern blot and RT-PCR analyses of total hepatic RNA. (J:40270)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any F11 Mutation: 55 strains or lines available

References

• Original: J:40270 Gailani D, et al., A murine model of factor XI deficiency. Blood Coagul Fibrinolysis. 1997 Mar;8(2):134-44
• All: 22 reference(s)