Fbln1^tm1Tmpl
Targeted Allele Detail

Summary

• Symbol: Fbln1^tm1Tmpl
• Name: fibulin 1; targeted mutation 1, Rupert Timpl
• MGI ID: MGI:2384028
• Gene: Fbln1 Location: Chr15:85090150-85170495 bp, + strand Genetic Position: Chr15, 40.27 cM, cytoband E-F
• Alliance: Fbln1^tm1Tmpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71581
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette into a XhoI site. Neither of the two known splice variants were detected in homozygous mutant mice by Northern blot or RT-PCR analyses of adult kidney tissue. Western blot analysis of blood plasma showed an absence of encoded protein. (J:71581)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbln1 Mutation: 30 strains or lines available

References

• Original: J:71581 Kostka G, et al., Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Mol Cell Biol. 2001 Oct;21(20):7025-34
• All: 5 reference(s)