Fgg^tm1Fjc
Targeted Allele Detail

Summary

• Symbol: Fgg^tm1Fjc
• Name: fibrinogen gamma chain; targeted mutation 1, Francis J Castellino
• MGI ID: MGI:2384029
• Synonyms: FG^-, Fib-
• Gene: Fgg Location: Chr3:82915031-82922356 bp, + strand Genetic Position: Chr3, 36.94 cM
• Alliance: Fgg^tm1Fjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64396
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette. Western blot analysis of blood plasma showed the absence of the gamma polypeptide, preventing the formation of the fibrinogen heterodimer in homozygous mutant mice. (J:64396)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fgg^tm1Fjc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgg Mutation: 30 strains or lines available

References

• Original: J:64396 Ploplis VA, et al., A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice. Am J Pathol. 2000 Sep;157(3):703-8
• All: 13 reference(s)