Angptl3^hypl
Spontaneous Allele Detail

Summary

• Symbol: Angptl3^hypl
• Name: angiopoietin-like 3; hypolipidemia
• MGI ID: MGI:2384031
• Synonyms: hypl
• Gene: Angptl3 Location: Chr4:98919191-98926429 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Angptl3^hypl page

Mutation origin

• Strain of Origin: KK/Snk

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Insertion
• A 4 bp insertion in exon 6 results in a stop codon at position 347. (J:75358)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl3 Mutation: 36 strains or lines available

Notes

Hypolipidemic KK/Snk animals exhibit 1/30-1/40 the amount of gene expression of KK animals.

References

• Original: J:75358 Koishi R, et al., Angptl3 regulates lipid metabolism in mice. Nat Genet. 2002 Feb;30(2):151-7
• All: 2 reference(s)