Fgr^tm2Hev
Targeted Allele Detail

Summary

• Symbol: Fgr^tm2Hev
• Name: FGR proto-oncogene, Src family tyrosine kinase; targeted mutation 2, Harold E Varmus
• MGI ID: MGI:2384041
• Synonyms: fgr-delta4
• Gene: Fgr Location: Chr4:132701406-132729204 bp, + strand Genetic Position: Chr4, 66.11 cM
• Alliance: Fgr^tm2Hev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16994
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette replaced exon 4 and precluded the complete translation of proteins initiated from a potential start codon at position 59 in the 3' terminal of exon 2. Normal protein was undetected by Western blot analysis of homozygous mutant mice, however, the lack of truncated carboxy terminal peptides was not directly verified. (J:16994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgr Mutation: 132 strains or lines available

References

• Original: J:16994 Lowell CA, et al., Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994 Feb 15;8(4):387-98
• All: 1 reference(s)