Cp^tm1Samd
Targeted Allele Detail

Summary

• Symbol: Cp^tm1Samd
• Name: ceruloplasmin; targeted mutation 1, Samuel David
• MGI ID: MGI:2384067
• Synonyms: Cp^-
• Gene: Cp Location: Chr3:20011218-20063309 bp, + strand Genetic Position: Chr3, 6.1 cM, cytoband D
• Alliance: Cp^tm1Samd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78092
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb region of the gene including exon 1 and the translation initiation site was replaced with a neomycin resistance cassette via homologous recombination. Southern blot analysis confirmed correct targeting of the allele and Western blot of plasma confirmed the absence of gene expression in homozygous mutant animals. (J:78092)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cp Mutation: 76 strains or lines available

References

• Original: J:78092 Patel BN, et al., Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 2002 Aug 1;22(15):6578-86
• All: 10 reference(s)