Loricrin^tm1Der
Targeted Allele Detail

Summary

• Symbol: Loricrin^tm1Der
• Name: loricrin cornified envelope precursor protein; targeted mutation 1, Dennis R Roop
• MGI ID: MGI:2384073
• Synonyms: Lor^-, Lor^tm1Der
• Gene: Loricrin Location: Chr3:91987578-91990447 bp, - strand Genetic Position: Chr3, 40.14 cM
• Alliance: Loricrin^tm1Der page

Delayed development of the skin barrier in Loricrin^tm1Der/Loricrin^tm1Der embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65187
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous locus was replaced with a neomycin selection cassette. The absence of transcript and protein was verified via RNAse protection assays, Western blot analysis, and indirect immunofluoresence microscopy. (J:65187)

Expression

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Loricrin Mutation: 12 strains or lines available

References

• Original: J:65187 Koch PJ, et al., Lessons from loricrin-deficient mice. Compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol. 2000 Oct 16;151(2):389-400
• All: 6 reference(s)