Gckr^tm1Bms
Targeted Allele Detail

Summary

• Symbol: Gckr^tm1Bms
• Name: glucokinase regulatory protein; targeted mutation 1, Bristol Myers Squibb
• MGI ID: MGI:2384075
• Synonyms: GKRP -
• Gene: Gckr Location: Chr5:31454787-31484658 bp, + strand Genetic Position: Chr5, 17.27 cM
• Alliance: Gckr^tm1Bms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58949
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern or Western blot analyses of liver tissue obtained from homozygous mutant mice. (J:58949)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gckr Mutation: 42 strains or lines available

References

• Original: J:58949 Farrelly D, et al., Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14511-6
• All: 1 reference(s)