Syk^tm1Tyb
Targeted Allele Detail

Summary

• Symbol: Syk^tm1Tyb
• Name: spleen tyrosine kinase; targeted mutation 1, Victor L J Tybulewicz
• MGI ID: MGI:2384078
• Synonyms: syk-
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29796
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin selection cassette disrupted the exon encoding the subdomain I of the kinase domain. The absence of protein in mice homozygous for the allele was verified by Western blot analysis. (J:29796, J:97055)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:29796 Turner M, et al., Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature. 1995 Nov 16;378(6554):298-302
• All: 80 reference(s)