Foxb1^tm1Pgr
Targeted Allele Detail

Summary

• Symbol: Foxb1^tm1Pgr
• Name: forkhead box B1; targeted mutation 1, Peter Gruss
• MGI ID: MGI:2384086
• Synonyms: Fkh5-
• Gene: Foxb1 Location: Chr9:69664992-69668222 bp, - strand Genetic Position: Chr9, 38.76 cM
• Alliance: Foxb1^tm1Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44764
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 1 and 2 were replaced with a neomycin selection cassette. The deleted region included the translational start site and the fork head domain. (J:44764)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxb1 Mutation: 16 strains or lines available

References

• Original: J:44764 Wehr R, et al., Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development. 1997 Nov;124(22):4447-56
• All: 2 reference(s)