Fshr^tm1Saco
Targeted Allele Detail

Summary

• Symbol: Fshr^tm1Saco
• Name: follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi
• MGI ID: MGI:2384087
• Synonyms: FORKO, Fshr-, FSH-R-
• Gene: Fshr Location: Chr17:89292380-89508103 bp, - strand Genetic Position: Chr17, 58.76 cM, cytoband E5
• Alliance: Fshr^tm1Saco page

Abnormal sperm morphology in Fshr^tm1Saco/Fshr^tm1Saco mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50933
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of a neomycin selection cassette deleted exon 1. Northern blot analysis of testicular and ovarian RNA showed that the deletion was sufficient for abbrogating the expression of all known isoforms. The absence of functional protein in homozygous mutant mice was confirmed by lableled ligand binding assays of testis. (J:50933)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fshr Mutation: 53 strains or lines available

References

• Original: J:50933 Dierich A, et al., Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13612-7
• All: 35 reference(s)