Mag^tm1Mtg
Targeted Allele Detail

Summary

• Symbol: Mag^tm1Mtg
• Name: myelin-associated glycoprotein; targeted mutation 1, Dirk Montag
• MGI ID: MGI:2384092
• Synonyms: Mag-, Mag-Ko, Mag^null
• Gene: Mag Location: Chr7:30598601-30614298 bp, - strand Genetic Position: Chr7, 19.26 cM
• Alliance: Mag^tm1Mtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:19475
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 5 via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of brain proteins from 26-day-old homozygous mutant animals. Immunohistochemical analysis of sciatic and optic nerve sections from 8-week-old homozygous mutants also failed to detect protein. (J:19475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mag Mutation: 25 strains or lines available

References

• Original: J:19475 Montag D, et al., Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron. 1994 Jul;13(1):229-46
• All: 16 reference(s)