Adipoq^tm1Tka
Targeted Allele Detail

Summary

• Symbol: Adipoq^tm1Tka
• Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Takashi Kadowaki
• MGI ID: MGI:2384094
• Synonyms: adipo^-
• Gene: Adipoq Location: Chr16:22965286-22976718 bp, + strand Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
• Alliance: Adipoq^tm1Tka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77876
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin resistance gene via homologous recombination. Absence of gene expression in adipose tissues of homozygous mutant animals was confirmed by Northern blot analysis. Protein product was undetectable in serum of homozygous mutants. (J:77876)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adipoq Mutation: 40 strains or lines available

References

• Original: J:77876 Kubota N, et al., Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem. 2002 Jul 19;277(29):25863-6
• All: 12 reference(s)