Rbms1^tm1Hiro
Targeted Allele Detail

Summary

• Symbol: Rbms1^tm1Hiro
• Name: RNA binding motif, single stranded interacting protein 1; targeted mutation 1, Hiroyoshi Ariga
• MGI ID: MGI:2384095
• Synonyms: Mssp^-
• Gene: Rbms1 Location: Chr2:60580537-60793536 bp, - strand Genetic Position: Chr2, 34.95 cM, cytoband C3
• Alliance: Rbms1^tm1Hiro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77893
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis. Western blot using polyclonal antibodies directed against amino acids 343-370 did not detect protein product in homozygous mutants. (J:77893)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbms1 Mutation: 48 strains or lines available

References

• Original: J:77893 Fujimoto M, et al., Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice. Genes Cells. 2001 Dec;6(12):1067-75
• All: 2 reference(s)