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a17R
Radiation induced Allele Detail
Summary
Symbol: a17R
Name: nonagouti; nonagouti 17 Oak Ridge
MGI ID: MGI:2384111
Synonyms: 58DSD, a58DSD
Gene: a  Location: Chr2:154792519-154892932 bp, + strand  Genetic Position: Chr2, 76.83 cM
Alliance: a17R page
Mutation
origin
Strain of Origin:  (101/Rl x C3H/Rl)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Undefined
 
Mutation detailsSequence analysis of cloned RT-PCR products comprising the entire coding region of the agouti locus showed no mutations; however, no regulatory sequences were investigated. Northern analysis showed agouti mRNA expression levels in skin of neonates homozygous for this allele to be significantly less than in wild-type controls. (J:75206)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any a Mutation:  463 strains or lines available
Notes
This allele has a severe phenotype. Phenotypes of a alleles can be categorized in ~8 week old mice according to the amount of yellow, phaeomelanin, pigment vs black, eumelanic, pigment (J75206): MILD: Banded hairs are present on the dorsum, sides, and ventrum, with yellow hair around nipples, perineum, and behind ears. MODERATE: Banded hairs are present in all body regions, but with reduced yellow. Dorsum is moderately darker than sides adjacent to the ventrum. Yellow is prominent around nipples, perineum, and behind ears. UMBROUS-LIKE: Yellow is severely reduced along dorsal midline. Banded hair is present on the sides and ventrum but with reduced yellow. Yellow is also reduced around nipples, perineum, and behind ears. SEVERE: Yellow is severely reduced in dorsum, sides, and ventrum and moderately reduced around nipples, perineum, and behind ears. NULL: Hairs are completely black with no yellow banding. No yellow is present around nipples, perineum, and behind ears.
References
Original:  J:75206 Miltenberger RJ, et al., Molecular and Phenotypic Analysis of 25 Recessive, Homozygous-Viable Alleles at the Mouse agouti Locus. Genetics. 2002 Feb;160(2):659-74
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory