a^1R
Radiation induced Allele Detail

Summary

• Symbol: a^1R
• Name: nonagouti; nonagouti 1 Oak Ridge
• MGI ID: MGI:2384121
• Synonyms: 37R145L, a^37R145L
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^1R page

Mutation origin

• Strain of Origin: (101/Rl x C3H/Rl)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: Sequence analysis of cloned RT-PCR products comprising the entire coding region of agouti showed a G to T base pair change at the terminal stop codon; this mutation is predicted to result in a stop to Leucine alteration at codon 132, and add 26 amino acids to the coding region. Wild-type levels of mRNA derived from this allele are detected. (J:75206)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

This allele has a mild phenotype. Phenotypes of a alleles can be categorized in ~8 week old mice according to the amount of yellow, phaeomelanin, pigment vs black, eumelanic, pigment (J75206): MILD: Banded hairs are present on the dorsum, sides, and ventrum, with yellow hair around nipples, perineum, and behind ears. MODERATE: Banded hairs are present in all body regions, but with reduced yellow. Dorsum is moderately darker than sides adjacent to the ventrum. Yellow is prominent around nipples, perineum, and behind ears. UMBROUS-LIKE: Yellow is severely reduced along dorsal midline. Banded hair is present on the sides and ventrum but with reduced yellow. Yellow is also reduced around nipples, perineum, and behind ears. SEVERE: Yellow is severely reduced in dorsum, sides, and ventrum and moderately reduced around nipples, perineum, and behind ears. NULL: Hairs are completely black with no yellow banding. No yellow is present around nipples, perineum, and behind ears.

References

• Original: J:75206 Miltenberger RJ, et al., Molecular and Phenotypic Analysis of 25 Recessive, Homozygous-Viable Alleles at the Mouse agouti Locus. Genetics. 2002 Feb;160(2):659-74
• All: 2 reference(s)