Frat1^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Frat1^tm1Brn
• Name: frequently rearranged in advanced T cell lymphomas; targeted mutation 1, Anton Berns
• MGI ID: MGI:2384128
• Synonyms: Frat1^-, Frat1^lacZ
• Gene: Frat1 Location: Chr19:41818409-41821022 bp, + strand Genetic Position: Chr19, 35.3 cM
• Alliance: Frat1^tm1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58550
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 660 nucleotides of the coding region were replaced with a cassette containing a lacZ beta-galactosidase gene and hygromycin selection gene. Expression of lacZ was driven by the endogenous promoter. Northern blot analysis confirmed the absence of transcript produced from the targeted locus. (J:58550)

Disease models

Expression

In Mice Carrying this Mutation:

79 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Frat1 Mutation: 9 strains or lines available

References

• Original: J:58550 Jonkers J, et al., In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech Dev. 1999 Nov;88(2):183-94
• All: 3 reference(s)