Foxb1^tm2Pgr
Targeted Allele Detail

Summary

• Symbol: Foxb1^tm2Pgr
• Name: forkhead box B1; targeted mutation 2, Peter Gruss
• MGI ID: MGI:2384129
• Synonyms: Foxb1 -, Foxb1-tau-lacZ
• Gene: Foxb1 Location: Chr9:69664992-69668222 bp, - strand Genetic Position: Chr9, 38.76 cM
• Alliance: Foxb1^tm2Pgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60093
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 1 and 2 were replaced with a cassette containing tau-lacZ and neo. The deleted region included the translational start site and the winged helix DNA binding domain. The expression pattern of beta-galactosidase recapitulated that of the endogenous gene. (J:60093)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxb1 Mutation: 16 strains or lines available

References

• Original: J:60093 Alvarez-Bolado G, et al., Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus. Development. 2000 Mar;127(5):1029-38
• All: 2 reference(s)