Id2^tm1Yyk
Targeted Allele Detail

Summary

• Symbol: Id2^tm1Yyk
• Name: inhibitor of DNA binding 2; targeted mutation 1, Yoshifumi Yokota
• MGI ID: MGI:2384134
• Synonyms: Id2-, Idb2^-
• Gene: Id2 Location: Chr12:25143798-25146091 bp, - strand Genetic Position: Chr12, 8.57 cM, cytoband B
• Alliance: Id2^tm1Yyk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53267
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.2 kb region of the gene including the promoter and an exon was replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis using the full cDNA sequence as a probe demonstrated the absence of gene expression in liver from homozygous mutant animals. (J:53267)

Expression

In Mice Carrying this Mutation:	7 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Id2^tm1Yyk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Id2 Mutation: 21 strains or lines available

References

• Original: J:53267 Yokota Y, et al., Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature. 1999 Feb 25;397(6721):702-6
• All: 64 reference(s)