Ltbr^tm1Kpf
Targeted Allele Detail

Summary

• Symbol: Ltbr^tm1Kpf
• Name: lymphotoxin B receptor; targeted mutation 1, Klaus Pfeffer
• MGI ID: MGI:2384140
• Synonyms: LTbetaR-, LTbetaRKO
• Gene: Ltbr Location: Chr6:125283534-125290848 bp, - strand Genetic Position: Chr6, 59.32 cM
• Alliance: Ltbr^tm1Kpf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48837
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb region of the gene from exon 1 to exon 5 was replaced with a neomycin resistance cassette via homologous recombination. The gene targeting event deletes bp 107-718 of the cDNA sequence. Northern blot analysis of liver from homozygous mutant animals using a full-length cDNA probe did not detect gene expression. Polyclonal antibodies directed against the extracellular domain of the protein did not react with mouse embryonic fibroblasts derived from homozygous mutant animals thus confirming the null allele. (J:48837)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltbr Mutation: 47 strains or lines available

References

• Original: J:48837 Futterer A, et al., The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 1998 Jul;9(1):59-70
• All: 102 reference(s)