Cdkn2a^tm2Brn
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm2Brn
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2, Anton Berns
• MGI ID: MGI:2384163
• Synonyms: Arf^F, Ink4a/Arf^F, Ink4a^flox, p16^INK4a-ARF^fl
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm2Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71393
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted 1.0 kb upstream of exon 2 and 1.5 kb downstream of exon 3. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Cdkn2a^tm2.1Brn. (J:71393)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm2Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:71393 Krimpenfort P, et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 2001 Sep 6;413(6851):83-6
• All: 28 reference(s)