Cdkn2a^tm2.1Brn
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm2.1Brn
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Anton Berns
• MGI ID: MGI:2384164
• Synonyms: Ink4a/Arf^-, Ink4a^delta2,3
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm2.1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71393
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by breeding mice carrying Cdkn2a^tm2Brn with transgenic mice expressing cre. The expression of cre recombinase resulted in the excision of exons 2 and 3. The deletion of this region affects the expression of both isoforms, p16^Ink4a and p19^ARF. (J:71393)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm2.1Brn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:71393 Krimpenfort P, et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 2001 Sep 6;413(6851):83-6
• All: 11 reference(s)