Cdkn2a^tm2.1Rdp
Targeted Allele Detail

Summary

• Symbol: Cdkn2a^tm2.1Rdp
• Name: cyclin dependent kinase inhibitor 2A; targeted mutation 2.1, Ronald DePinho
• MGI ID: MGI:2384177
• Synonyms: Ink4a^-, p16-, p16^Ink4a-, p16^Ink4a-
• Gene: Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
• Alliance: Cdkn2a^tm2.1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71394
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 alpha, specific to the p16^Ink4a alternative splice product, was replaced by a floxed neo cassette. Cre mediated recombination removed the floxed neo cassette. The absence of the p16^Ink4a and the presence of p19^ARF was confirmed by Western blot analysis of extracts from homozygous mutant mouse embryonic fibroblasts. (J:71394)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm2.1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2a Mutation: 67 strains or lines available

References

• Original: J:71394 Sharpless NE, et al., Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 2001 Sep 6;413(6851):86-91
• All: 86 reference(s)