Shc1^tm1Ravi
Targeted Allele Detail

Summary

• Symbol: Shc1^tm1Ravi
• Name: src homology 2 domain-containing transforming protein C1; targeted mutation 1, Kodi S Ravichandran
• MGI ID: MGI:2384183
• Synonyms: Shc^fl
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^tm1Ravi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78180
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 1 and 2, encoding the transcriptional start site and the amino terminals of the three known isoforms, were flanked by a single upstream loxP site and a floxed neo cassette inserted into intron 2. Transient transfection of ES cells resulted in the excision of the floxed neo cassette, leaving the first two exons surrounded by single loxP sites. (J:78180)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:78180 Zhang L, et al., A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol. 2002 Aug;3(8):749-55
• All: 7 reference(s)