Mlh3^tm1Lpkn
Targeted Allele Detail

Summary

• Symbol: Mlh3^tm1Lpkn
• Name: mutL homolog 3; targeted mutation 1, Steven M Lipkin
• MGI ID: MGI:2384218
• Synonyms: Mlh3^-
• Gene: Mlh3 Location: Chr12:85281294-85317373 bp, - strand Genetic Position: Chr12, 39.61 cM
• Alliance: Mlh3^tm1Lpkn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78200
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 and downstream intronic sequence were replaced with a cassette containing lacZ and neo. Transcript was undetected by Nothern blot analysis of total testicular RNA. Immunofluorescence analysis of chromosomes during the meiosis I pachytene stage showed an absence of protein in homozygous mutant mice. (J:78200)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mlh3^tm1Lpkn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mlh3 Mutation: 78 strains or lines available

References

• Original: J:78200 Lipkin SM, et al., Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet. 2002 Aug;31(4):385-90
• All: 15 reference(s)