Birc5^tm1Emc
Targeted Allele Detail

Summary

• Symbol: Birc5^tm1Emc
• Name: baculoviral IAP repeat-containing 5; targeted mutation 1, Edward M Conway
• MGI ID: MGI:2384336
• Synonyms: survivin-
• Gene: Birc5 Location: Chr11:117740077-117746569 bp, + strand Genetic Position: Chr11, 82.96 cM, cytoband E2
• Alliance: Birc5^tm1Emc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78103
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 6.5 kb region containing the entire gene (exons 1-4) was replaced with a lox-P flanked neomycin cassette via homologous recombination. A low percentage of homozygous mutant embryos were observed at 3.5 days post coitum. (J:78103)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc5 Mutation: 20 strains or lines available

References

• Original: J:78103 Conway EM, et al., Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways. Gastroenterology. 2002 Aug;123(2):619-31
• All: 5 reference(s)