Foxb1^tm1Lby
Targeted Allele Detail

Summary

• Symbol: Foxb1^tm1Lby
• Name: forkhead box B1; targeted mutation 1, Patricia A Labosky
• MGI ID: MGI:2384415
• Synonyms: Foxb1^taulacZ-
• Gene: Foxb1 Location: Chr9:69664992-69668222 bp, - strand Genetic Position: Chr9, 38.76 cM
• Alliance: Foxb1^tm1Lby page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67882
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the endogenous gene was replaced with a cassette containing a tau-lacZ fusion gene linked to an IRES. Staining showed the expression pattern of beta-galactosidase to be similar to that of the endogenous gene. (J:67882)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxb1 Mutation: 16 strains or lines available

References

• Original: J:67882 Kloetzli J, et al., The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex. Genesis. 2001 Feb;29(2):60-71
• All: 1 reference(s)