Foxb1^tm1Sli
Targeted Allele Detail

Summary

• Symbol: Foxb1^tm1Sli
• Name: forkhead box B1; targeted mutation 1, Suzanne C Li
• MGI ID: MGI:2384416
• Synonyms: TWH^(-)
• Gene: Foxb1 Location: Chr9:69664992-69668222 bp, - strand Genetic Position: Chr9, 38.76 cM
• Alliance: Foxb1^tm1Sli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40032
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An nls-lacZ gene replaced approximately 60% of the coding region including the entire DNA-binding domain. Comparison of Xgal staining and in situ hybridization showed that the expression pattern of beta-galactosidase was similar to that of the endogenous gene during development. (J:40032)

Expression

In Mice Carrying this Mutation:	140 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxb1 Mutation: 16 strains or lines available

References

• Original: J:40032 Dou C, et al., TWH regulates the development of subsets of spinal cord neurons. Neuron. 1997 Apr;18(4):539-51
• All: 1 reference(s)