Egr1^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Egr1^tm1Jmi
• Name: early growth response 1; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2384433
• Synonyms: egr-1-, Egr1^-, Egr-1⁰, Egr-1^ko, NGFI-A^-
• Gene: Egr1 Location: Chr18:34994260-34998009 bp, + strand Genetic Position: Chr18, 18.76 cM, cytoband C/D
• Alliance: Egr1^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24948
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into a coding exon upstream of the DNA-binding domain via homologous recombination. The targeted mutation introduces several stop codons resulting protein truncation upstream of the DNA-binding domain. Gene expression and protein product were not observed in homozygous mutant ES cells. (J:24948)

Disease models

Expression

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Egr1^tm1Jmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egr1 Mutation: 21 strains or lines available

Notes

ES cell line = AB1 (129S7/SvEvBrd-Hprt⁺) or D3 (129S2/SvPas).

References

• Original: J:24948 Lee SL, et al., Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J Biol Chem. 1995 Apr 28;270(17):9971-7
• All: 99 reference(s)