Sim2^tm1Shmb
Targeted Allele Detail

Summary

• Symbol: Sim2^tm1Shmb
• Name: single-minded family bHLH transcription factor 2; targeted mutation 1, M J Shamblott
• MGI ID: MGI:2384488
• Synonyms: Sim2 -/-, Sim2^tm1Jdg
• Gene: Sim2 Location: Chr16:93885963-93927891 bp, + strand Genetic Position: Chr16, 55.05 cM, cytoband C3.3-C4
• Alliance: Sim2^tm1Shmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78252
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence, encoding the initiator methionine and the first 47 amino acids of the basic helix-loop-helix domain, was deleted from exon 1 by the insertion of a neomycin cassette via homologous recombination. (J:78252)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim2 Mutation: 23 strains or lines available

References

• Original: J:78252 Shamblott MJ, et al., Craniofacial abnormalities resulting from targeted disruption of the murine Sim2 gene. Dev Dyn. 2002 Aug;224(4):373-80
• All: 2 reference(s)