Etv1^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Etv1^tm1Tmj
• Name: ets variant 1; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:2384493
• Synonyms: Er81^ETS
• Gene: Etv1 Location: Chr12:38829655-38920484 bp, + strand Genetic Position: Chr12, 17.99 cM
• Alliance: Etv1^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78232
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct containing an IRES-tau-lacZ cassette inserted in place of exon 11 was incorporated into the endogenous locus via homologous recombination. The insertion disrupted sequence encoding part the ETS domain and inserted stop codons into all three reading frames. Normal protein was undetected in homozygous mutant mice. No beta-galactosidase activity is detected. (J:78232)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Etv1^tm1Tmj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv1 Mutation: 44 strains or lines available

References

• Original: J:78232 Arber S, et al., ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
• All: 11 reference(s)