Etv1^tm2Tmj
Targeted Allele Detail

Summary

• Symbol: Etv1^tm2Tmj
• Name: ets variant 1; targeted mutation 2, Thomas M Jessell
• MGI ID: MGI:2384496
• Synonyms: Er81^nlslacZ, Er81^NLZ
• Gene: Etv1 Location: Chr12:38829655-38920484 bp, + strand Genetic Position: Chr12, 17.99 cM
• Alliance: Etv1^tm2Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78232
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing nls-lacZ was inserted in frame into exon 2. While normal protein was undetected in homozygous mutant embryos at E13.5, approximately 5% of dorsal root ganglion neurons showed reactivity after E15. The authors believe the expression to be that of inactive protein lacking the activation domain. (J:78232)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Etv1 Mutation: 44 strains or lines available

References

• Original: J:78232 Arber S, et al., ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 2000 May 26;101(5):485-98
• All: 13 reference(s)