Ltb^tm1Krn
Targeted Allele Detail

Summary

• Symbol: Ltb^tm1Krn
• Name: lymphotoxin B; targeted mutation 1, Heinrich Korner
• MGI ID: MGI:2384499
• Synonyms: LTbeta^-
• Gene: Ltb Location: Chr17:35413483-35415281 bp, + strand Genetic Position: Chr17, 18.59 cM
• Alliance: Ltb^tm1Krn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78229
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Exon 1 was disrupted by the insertion of a neomycin selection cassette via homologous recombination. (J:78229)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltb Mutation: 19 strains or lines available

References

• Original: J:78229 Wilhelm P, et al., Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs. Eur J Immunol. 2002 Jul;32(7):1993-2003
• All: 19 reference(s)