Lta/Tnf^tm1Jods
Targeted Allele Detail

Summary

• Symbol: Lta/Tnf^tm1Jods
• Name: tumor necrosis factor; targeted mutation 1, Jonathon D Sedgwick
• MGI ID: MGI:2384506
• Synonyms: B6.TNF/LTalpha^-, TNF-alpha^-/LTalpha^-, TNF/LTalpha-
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Lta/Tnf^tm1Jods page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43602
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The insertion of a neomycin selection cassette replaced approximately 4.0 kb of sequence, containing the entire coding region of Lta and exons 1 through 3 of Tnf. RT-PCR analysis indicated that transcript was not produced from the targeted loci. (J:43602)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

Notes

ES cell lines = BL/6-III or Bruce 4

References

• Original: J:43602 Korner H, et al., Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol. 1997 Oct;27(10):2600-9
• All: 24 reference(s)