H2-DMa^tm1Doi
Targeted Allele Detail

Summary

• Symbol: H2-DMa^tm1Doi
• Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:2384509
• Synonyms: DM⁰, H2-DMa^tm1Dim, H-2M^o, Ma-, M^o
• Gene: H2-DMa Location: Chr17:34338667-34358075 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-DMa^tm1Doi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31624
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing all of exon 1 and a portion of exon 2 was replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via RT-PCR analysis of total spleen RNA. (J:31624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-DMa Mutation: 27 strains or lines available

References

• Original: J:31624 Miyazaki T, et al., Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 1996 Feb 23;84(4):531-41
• All: 11 reference(s)