Tgfbr2^tm1Hlm
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1Hlm
• Name: transforming growth factor, beta receptor II; targeted mutation 1, Harold L Moses
• MGI ID: MGI:2384511
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1Hlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75073
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A construct, in which exon 2 was surrounded by a loxP site in intron 1 and a floxed neo gene in intron 2, was incorporated at the endogenous locus via homologous recombination. (J:75073)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr2^tm1Hlm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
• All: 41 reference(s)