Tgfbr2^tm1.1Hlm
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1.1Hlm
• Name: transforming growth factor, beta receptor II; targeted mutation 1.1, Harold L Moses
• MGI ID: MGI:2384512
• Synonyms: -Exon2/-Neo^r
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1.1Hlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75073
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is derived from Tgfbr2^tm1Hlm. Expression of cre recombinase at the one cell stage resulted in the excision of the floxed region containing exon 2, neo, and an intervening loxP site. (J:75073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
• All: 2 reference(s)