Tgfbr2^tm1.2Hlm
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1.2Hlm
• Name: transforming growth factor, beta receptor II; targeted mutation 1.2, Harold L Moses
• MGI ID: MGI:2384513
• Synonyms: +Exon2/-Neo^r, floxed-Tbr2, TbetaRII^flox+, TbetaRII^flox, Tbr2^fl, TGFbeta IIR^fl, TGFbetaRII^f, Tgfbr2^E2flx, Tgfbr2^fl, Tgfbr2^floxE2, Tgfbr2^loxP, Tgfbr^floxE2
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1.2Hlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75073
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is derived from Tgfbr2^tm1Hlm. Expression of cre recombinase at the one cell stage resulted in the excision of the floxed region containing the neo transgene. Two single loxP sites were left flanking exon 2. (J:75073)

Disease models

Expression

In Mice Carrying this Mutation:	135 assay results 5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfbr2^tm1.2Hlm

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:75073 Chytil A, et al., Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis. 2002 Feb;32(2):73-5
• All: 195 reference(s)